Benzodiazepines (Xanax, Klonopin, Halcion, and Librium).When too great of a dose is taken, possible outcomes include overdose and death. Lack of oxygen is the biggest risk of abusing downers. This can cause dangerously low oxygen levels in the body and result in a coma. Illegal sedatives such as narcotics, are never safe to abuse in any amount, and are notorious for being highly addictive.ĭepressants slow central nervous system functions, such as breathing and heart rate. Legal s edatives are helpful in managing anxiety, epilepsy, and insomnia, but are dangerous when abused. The natural opposites of uppers, downers decrease alertness and focus. They make the individual feel relaxed or drowsy and are often highly effective at minimizing feelings of pain. This slang term refers to CNS depressants, the types of drug that produce a sedative effect by slowing down the messages sent and recieved between the central nervous system and brain. On the opposite end of the drug side effect spectrum are downers. Cocaine may go by coke, dust, snow, blow, or white. Amphetamines like Adderall and Ritalin may go by nicknames such as speed, jelly beans, or addys. One of the key ways to know what you or a loved one is taking is by knowing the nicknames of various uppers. Such an occurrence is even more likely with the use of illict stimulants, which are extremely powerful and have no safe levels of use. However, take too much, and the side effect of overstimulation is likely to result in cardiac distress such as high blood pressure, irregular hearbeats, heart failure, or a stroke. Legal stimulants, like coffee or ADHD medications, can be helpful for improving focus and concentration. Feelings of exhaustion and depression set in and users seek more uppers to ward of what’s known as a “crash”.

This is similar to what stimulant drug users epxerience once a stiumlant wears off. If you’ve ever felt an adrenaline rush before, you likely felt shaky, weak, or dizzy once it passed. Uppers increased cardiovascular and respiratory functions to dangerous degrees that can overwhelm the body. The high that uppers produce is invigorating, but the result of a process that puts tremendous strain on the body. Stimulants work by speed up the messages that are sent and recieved between the brain and the central nervous system (CNS). Uppers is a slang term used to refer to stimulants, a group of drugs that increase energy, alertness, and mood, and can also heighten feelings of self-confidence or sexual prowress.

Getting Help for a Stimulant or Depressant Addiction.

Cross Drug Use: Combining Uppers and Downers.

These data indicate this solid phase extraction method is effective for routine and high-volume testing of amphetamine drugs. Analysis of a sample size of 2 milliters provided a detection limit of 50 nanograms/milliliter within a calibration range of 250 to 4000 ng/ml using a second order polynomial model. Reproducibility was less than a 5- percent coefficient of variation. With d9-MAP as the internal standard, the corresponding values were 66, 81, and 95 percent. Using d5AMP as the internal standard, the recovery was 66, 81, and 97 percent for AMP, METH, and MDMA, respectively. The first of the ions listed for each compound was used for quantitation. Gas chromatographic/mass spectrometric analysis was performed with selected ion monitoring of the following ions: 190, 91, 188 204, 91, 202 162, 135, 202 194, 123 and 211, 209 for the derivatized amphetamine (AMP), methamphetamine (MAP), 3,4- methylenedioxymethamphetamine (MDMA), d5-AMP, and d9-MAP, respectively. The recovery process included column manufacturer extraction procedures, trichloroacetic anhydride derivatization, and the addition of a simple cleanup step prior to the derivatization.

Amphetamine example